What Medicine Reduces Fever? Exploring Options
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What Medicine Reduces Fever? Exploring Options

19 Dec 2023

For those wondering what medicine reduces fever, several medicines and over-the-counter (OTC) treatment options are available. Fevers are often a symptom of various illnesses, which can be distressing and sometimes alarming. Fortunately, there are ways to reduce fever and alleviate the discomfort that often comes with it.

By understanding the various options for reducing fever, you can make informed decisions about which treatment is most appropriate for your specific needs for a faster recovery

What Type of Medicine Reduces Fever?

Whether you have a low-grade fever or severe, you should always understand your medication options first. Fever-reducing medications fall primarily into two categories: antipyretics and nonsteroidal anti-inflammatory drugs (NSAIDs).

Antipyretics, such as acetaminophen, work directly on the brain's temperature-regulating center (the hypothalamus) to lower body temperature. They’re highly effective in reducing fever and alleviating associated discomfort.

NSAIDs, including ibuprofen and aspirin, not only reduce fever but they also possess anti-inflammatory properties. These ingredients can be particularly beneficial when fever is accompanied by inflammation during infections.

NSAID medications work by inhibiting the production of prostaglandins, which are responsible for the body's inflammatory response.

Types of Fever Reducers

There are several types of fever reducers, each with its own mechanism of action and suitability for different situations. The most common types of fever reducers include acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), and aspirin.


One of the most commonly used antipyretic medications is acetaminophen. Acetaminophen is known for its fever-reducing properties and is a popular choice for adults and children. It's available in various forms, including liquid and tablets, making it convenient and easy to administer.

Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

Ibuprofen has excellent fever-reducing properties. They work by preventing the production of certain chemicals in the body, causing inflammation and fever. These medications are often used to provide relief from symptoms like headaches and muscle aches. Use NSAIDs cautiously, as they may have side effects, especially if taken in high doses or over an extended period.


A type of NSAID, aspirin, can also be used as a fever reducer. According to the Cleveland Clinic, NSAIDs work by inhibiting the production of prostaglandins, which helps lower body temperature. Aspirin has been widely used for its fever-reducing and anti-inflammatory properties.

However, aspirin isn’t recommended for children or teenagers with fever due to the risk of Reye's syndrome— a rare but serious condition.

When choosing a fever reducer, it's important to consider factors like your age, medical history, and any existing medical conditions. Consult with a healthcare professional or pharmacist to determine the most suitable fever reducer for your specific situation.

Fever Reducers for Children

For children’s fever, you want the best medicine, starting with a fever reducer. Fever reducers for children are essential tools for managing their body temperature and discomfort from related symptoms.

Acetaminophen for Minors

One of the most commonly recommended options for children is acetaminophen. This fever reducer is available in liquid form and suitable for various age groups, making it easier to administer to children. It’s crucial to follow the dosing instructions carefully, as the correct dosage depends on the child's age and weight.

Acetaminophen not only reduces fever but it also relieves pain. It’s often used to manage common childhood ailments like colds and flu.

Mucinex® Children’s Cold & Flu (All-in-One) Very Berry Flavor is an effective children’s fever reducer while alleviating sore throat, headache, sinus pressure, and more.

Ibuprofen for Minors

Another option for reducing fever in children is ibuprofen, which is found in OTC medications. Ibuprofen is also available in liquid form, making it convenient for pediatric use. It’s effective at lowering a child’s temperature and has anti-inflammatory properties, providing relief from various pain-related symptoms.

As with acetaminophen, it's crucial to adhere to the recommended dosages based on the child's age and weight, and it should be administered with care to avoid any potential side effects.

However, according to the Mayo Clinic, ensure you avoid aspirin for children because it isn’t typically recommended due to the risk of Reye's syndrome.

Fever Reducers for Adults

Fever reducers for adults help alleviate discomfort and manage fever, which is often a symptom of various underlying conditions.

Acetaminophen for Adults

Among the most commonly used fever reducers for adults are acetaminophen, ibuprofen, and aspirin. A great option to reduce fever and alleviate headaches, body pain, sore throats, cough, chest congestion and nasal congestion symptoms is Mucinex® Maximum Strength Fast-Max® Cold, Flu & Sore Throat.

Acetaminophen is often used to manage common ailments such as colds, flu, and headaches. It is known for its effectiveness and relatively low risk of stomach irritation, making it a well-tolerated option for most people.

Ibuprofen for Adults

Ibuprofen is another common fever reducer for adults. Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen have the dual benefit of reducing fever and alleviating inflammation and pain.

They work by halting enzymes that produce substances causing inflammation and fever. Like acetaminophen, use ibuprofen as directed and be mindful of any potential side effects, especially for those with specific medical conditions or medications that may interact with it.

Aspirin, a type of NSAID, is another option for adults to lower fever and reduce inflammation. For adults, aspirin can be a suitable choice, but like other fever-reducing medicines, it must be used with care, and it's important to be aware of potential side effects.

Is Acetaminophen or Ibuprofen Better for Fever?

When it comes to choosing between acetaminophen and ibuprofen for fever relief, there are several factors you should consider. Both medications are effective at reducing fever, but they work in slightly different ways.

Acetaminophen, also known as paracetamol, is primarily used for pain and fever reduction. It's considered a good option for those who can't tolerate anti-inflammatory drugs like ibuprofen or have conditions that contraindicate their use. It's generally considered easier on the stomach and is often preferred when an individual has gastrointestinal sensitivities.

On the other hand, ibuprofen is a non-steroidal anti-inflammatory drug (NSAID). It not only reduces fever but it also has anti-inflammatory properties. This can be particularly beneficial if fever is accompanied by inflammation, such as in the case of some infections.

Acetaminophen for Fevers Ibuprofen for Fevers (NSAID)

Pain and fever relief

Pain, inflammation, and fever relief

Low risk of stomach irritation side effects

Potential side effects of stomach irritation

Anti-inflammatory drug

Non-steroidal anti-inflammatory drug


However, individuals with certain medical conditions, like peptic ulcers, might be advised to avoid NSAIDs due to their potential to irritate the stomach lining.

The choice between acetaminophen and ibuprofen for fever relief should also consider individual factors such as allergies, existing medical conditions, and current medications.

In many cases, either medication can effectively reduce fever, but consulting a healthcare professional is advisable, especially when dealing with high fevers, persistent symptoms, or for those with specific medical concerns.

My Fever Won’t Go Down – What Should I Do?

There are many causes of a fever. When your fever persists and won't subside despite taking fever-reducing medication, it can be concerning. In such cases, there are several steps you can take to address the issue effectively.

Follow the Directions on Medication Labels Correctly

First and foremost, ensure you’re using the medication correctly by following the recommended dosages and guidelines. Overdosing or not adhering to the instructions can lead to complications and may not provide the desired relief.

Consult a Healthcare Professional

If your fever persists or worsens, contact your doctor or other healthcare professional. A persistent fever may be a sign of an underlying medical condition that needs attention.

Your healthcare provider can help diagnose the cause of your elevated temperature and recommend the right treatment.

In some cases, additional testing or evaluation may be necessary to identify the root of the issue.

Stay Hydrated

In the meantime, focus on getting plenty of fluids, getting plenty of rest, and keeping your body cool by wearing lightweight clothing and using a fan or a cool compress.

These measures can help alleviate discomfort while you work with a healthcare professional to determine the cause of your persistent fever and find the best course of action for a full recovery.

OTC Fever Reducer Medications

Fever-reducing medications are an effective way to treat fever and alleviate discomfort when you’re sick. From acetaminophen to NSAIDs like ibuprofen to aspirin, there is a range of treatment options, each with unique features and considerations.

When using fever reducers, always follow dosing instructions carefully and consult with your doctor when necessary, particularly in cases of persistent or severe fever. When you understand these medications, you can make better choices to manage your fever effectively and get back to health with greater comfort and ease.

  1. Cleveland Clinic (2022), Prostaglandins
  2. Mayo Clinic (2023), Reye’s syndrome
  3. National Library of Medicine (2017), Peptic ulcer disease and non-steroidal anti-inflammatory drugs
  4. National Library of Medicine (2022), Physiology, Fever
  5. Northwestern Medicine (2020), Quick Dose: Can Ibuprofen Reduce Menstrual Flow?
  6. Better Health Channel (2021), Medications - non-steroidal anti-inflammatory drugs
  7. Journal of Pain and Symptom Management (2013), Acetaminophen (Paracetamol)

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